Endorphins are responsible for blocking pain signals, while endocannabinoids bind to cannabinoid receptor

As for how the release of dobaan is regulated, there seems to be much room for scientific discussion and clarification. Photo Credit: Sports Horizons Johannes Fuss published a very interesting study in 2015. They found that cannabinoid receptor 1 (CB1) is the main regulator of runner’s high through transgenic mice and behavioral analysis, and this discovery Could explain why dopamine alone is not enough to make a runner high. During running, the body releases dopamine and endocannabinoid (eCB) into the bloodstream.


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Endorphins are responsible Namibia Phone Number for blocking pain signals, while endocannabinoids bind to cannabinoid receptor 1 on GABAergic neurons to block the downstream inhibition of dopamine-secreting neurons. Inhibit signaling, which makes dopamine-secreting neurons more likely to activate and produce dopamine. In the experiment, they divided the mice into a running group and a non-running group. Five hours the behavioral test. The mice in the running group were allow. To run freely on the rollers. And immediately after the rollers retract. the mice were given a light-dark anxiety behavioral test.


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Mice like to stay in a dark place that makes them feel more secure, so this experiment can use the time mice spend exploring in a bright place as an indicator of anxiety. The longer the time in the bright place, the lower the anxiety value. They found that mice in the running group spent significantly longer in the light than the non-running control group, and mice in the running group were also significantly less sensitive to pain on subsequent pain tests. After the behavioral test. The mice in all groups were immediately open. To run the roller for one hour. It  found  the total distance run by the mice in the runn group. After the test significantly lower than that in the control group. Did not run before. The mice in the group  relatively calmer . The mice in the control group  the test. From their animal experiments. They can see that the mice experience psychological changes similar to .runners  for a long time.but “happy mood” cannot be measur. Because it is very subjective comparto other pleasure-oriented emotions, so it is impossible to measure it. It is clearly defined in animal experiments.

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